Cultural exchange and internationalization—the process of integrating an international, intercultural, or global dimension into the functions and delivery of higher education—have increased markedly in significance within higher education in the last few years. In the broadest sense, this agenda is about preparing students for living in and contributing to an increasingly connected global society. At a time when the political and social trend seems to be toward exclusionism, exposing students to a vibrant blend of ideas, opinions, and experiences within the stimulating, yet safe, space of university resonates all the more strongly. However, historically it has been difficult to encourage students to participate fully, particularly with regard to student mobility and studying abroad. Socioeconomic and cultural factors play an important role here. This case study investigates the design and rollout of an innovative online international exchange program carried out between Abertay University in Dundee, Scotland, and DePaul University in Chicago, IL. As part of their core mission, both institutions are committed to widening participation, and both have a high proportion of first-generation students from the lowest socioeconomic groups. Consequently, the student mobility rate at both universities is low, which limits opportunities for students to situate their learning within a global context. Recent developments in digital communications and platform sharing technologies have allowed universities to explore online collaboration and virtual exchange, but this raises new challenges. In particular, how do you embed a sense of genuine cultural exchange and collaboration between students who are geographically remote, very possibly in different time zones, and—crucially—still enmeshed in their local culture? This paper outlines an innovative and practical response to that problem, using a collaborative project in which students must serve as both directors and clients in the production of creative sound works to facilitate a profound and meaningful cultural exchange. The paper outlines the design and implementation of this online student exchange program; discusses the challenges, benefits, and drawbacks to the approach; and concludes by generalizing from this particular case to discuss how discipline-specific skills can be used as a mechanism to build cohesive and outward-looking cohorts of students, even when they are not colocated on campus.